Exclusive: Frontiers of Technology Ethics

Ethical review of clinical trial conditions for human heritable genome editing

  • Lingzhi WANG , 1, 2 ,
  • Bin ZHOU 2
Expand
  • 1. Department of Civics, Fenyang College of Shanxi Medical University, Fenyang 032200, China
  • 2. School of Philosophy, Shanxi University, Taiyuan 030006, China

Received date: 2023-11-25

  Online published: 2025-04-01

Copyright

All rights reserved. Unauthorized reproduction is prohibited.

Cite this article

Lingzhi WANG , Bin ZHOU . Ethical review of clinical trial conditions for human heritable genome editing[J]. Science & Technology Review, 2025 , 43(4) : 61 -66 . DOI: 10.3981/j.issn.1000-7857.2023.11.01688

1
美国国家科学院, 美国国家医学院. 人类基因组编辑: 科学、伦理和监督[M]. 北京: 科学出版社, 2019.

2
中华人民共和国科学技术部. 人类基因组编辑研究伦理指引[EB/OL]. (2024-07-08)[2025-01-26]. https://www.most.gov.cn/kjbgz/202407/t20240708_191311.html.

3
罗纳德·蒙森. 干预与反思: 医学伦理学基本问题[M]. 林侠, 译. 北京: 首都师范大学出版社, 2010: 953-954.

4
Bolukbasi M F , Gupta A , Wolfe S A . Creating and evaluating accurate CRISPR-Cas9 scalpels for genomic surgery[J]. Nature Methods, 2015, 13 (1): 41.

5
珍妮佛·杜德娜, 塞缪尔·斯滕伯格. 破天机: 基因编辑的惊人力量[M]. 傅贺, 译. 长沙: 湖南科学技术出版社, 2020: 175.

6
Nuffield Council on Bioethics. Heritable genome editing and human reproduction: Social and ethics Issues[EB/OL]. [2025-01-27].http://nuffieldbioethics.org/project/genome-editing-human-reproduction.

7
斯蒂恩. DNA和命运: 人类行为的天性和教养[M]. 李恭楚, 吴希美, 译. 上海: 上海科学技术出版社, 2001: 15.

8
Childress J F , Beauchamp T L . Principles of biomedical ethics[M]. New York: Oxford University Press, 2001: 76.

9
Robertson J A . Children of choice[M]. New Jersey: Princeton University Press, 1994: 23- 24.

10
Malina D , Rosenbaum L . The future of gene editing-to-ward scientific and social consensus[J]. New England Journal of Medicine, 2019, 380 (10): 971- 975.

11
International Commission on The Clinical Use of Human Germline Genome Editing . Heritable human genome editing[M]. Washington: The National Academies Press, 2020: 100.

12
Glenn C , Adashi Eli Y . Legal and ethical issues in the report heritable human genome editing[J]. The Hastings Center Report, 2021, 51 (3): 8- 12.

13
最高人民法院、最高人民检察院关于办理侵犯公民个人信息刑事案件适用法律若干问题的解释[EB/OL]. (2017-05-08)[2024-03-18]. https://flk.npc.gov.cn/detail2.html?NDAyODgxZTQ1ZmZiYmU0MTAxNWZmYmZjMTExYTAzNTA%3D.

14
张新宝. 隐私权的法律保护[M]. 北京: 群众出版社, 1997: 13.

15
罗纳德·德沃金. 至上的美德: 平等的理论与实践[M]. 冯克利, 译. 南京: 江苏人民出版社, 2008: 475-478.

16
Saunders B . First, do no harm: Generalized procreative non-maleficence[J]. Bioethics, 2017, 31 (7): 552- 558.

Outlines

/