Combined with the large span, heavy load, stability, durability, and high requirement for fire prevention and anti-corrosion, the optimized structure should be a post-tensioned bonded prestressed concrete frame structure, and the overall structure has good mechanical properties. Starting from three macro directions of analysis model establishment, the crack control, and bearing capacity calculation, the detail design process for long-span posted-tensioned bonded prestressed beams is introduced. Some problems, such as degree of the relative height of equivalent compression zone, partial presstressing ratio, rate of tension reinforcing steel bar, and non-prestressed reinforcement area ratio, are discussed and the treatments are put forward. As indicating in the results, for developing a reasonable tension construction scheme, some construction measures for the core areas of tension are suggested, and the design experience could be referred to similar engineering projects.