This paper studies the epidemiology of depression in view of syndrome characteristics of traditional Uighur Medicine. Epidemiological investigation for syndrome characteristics of traditional Uighur medicine in depression patients who were stayed in the department of clinical psychology of the First Affiliated Hospital of Xinjiang Medical University was conducted, including general information, clinical symptoms, Hamilton depression rating scale (HAMD) and statistical analysis. The results show that the female patients outnumber the male patients. Patients aging between 40-52 outnumber other aging groups (27.36%). The number proportion in four abnormal Hilit groups is in the following order: Abnormal Savda group>Abnormal Sapra group>Abnormal Balgham group>Abnormal Khan group. There is no significant difference between four groups when compared to their HAMD scale (P>0.05). It is concluded that the Abnormal Savda is the main syndrome of depression in the traditional Uighur Medicine.