To investigate the relationship between changes of prethrombotic state with coronary heart diseases and traditional Urgur medicine syndromes on coronary heart diseases. 245 patients with coronary heart diseases were randomly selected and then grouped according to the traditional Urgur medicine theories. The expression of CD62p on platelets, the level of plasma tissue Plasminogen Activator (t-PA), the level of Serum Endothelin (ET-1), the Activated Partial Thromboplastin Time (APTT), the Fibrinogen (FIB), the Nprothrombin Time(PT), and the Thrombin Time(TT) were determined by flow cytometer, enzyme-linked immunosorbnent assay,radioimmunoassay method, and auto coagulometer. Compared to the control group, the levels of CD62p, FIB, PAI and ET-1 are increased in the abnormal savda group and the non-abnormal savda(abnormal khan, abnormal sepra and abnormal belghem)group (P<0.05); the level of t-PA is decreased in the abnormal savda group and the non-abnormal savda group (P<0.05); the APTT and PT are shortened in the abnormal savda group and the non-abnormal savda group (P<0.05), There are no significant changes of CD41 and TT in all groups (P>0.05). Compared to the abnormal savda group, the level of ET-1 is increased in the abnormal khan and abnormal sepra group(P<0.05), the level of CD62p is increased in the abnormal belghem group(P<0.05),there are no significant differences of the levels of CD41, t-PA, PAI-1, PT, TT and APTT in patients with different traditional Urgur medicine syndrome groups (P>0.05). There is the prethromboitic state in all different Urgur abnormal syndrome groups of coronary heart diseases, which can be observed in the injury of vessel epithelial cells, increased platelet activity, increased blood viscosity, decreased fibronolytic function. The prethromboitic state of the abnormal savda syndrome group with coronary heart diseases is more obvious than other abnormal syndrome groups.