The animal models of human disease could facilitate the studies of disease pathogenesis and the development of new drugs and treatments. It is an essential step in the preclinical research and the translational medicine studies of Bench to Bedside(B2B). The animal models established by the genetic modification are paid particular attentions due to their genetic stability and repeatable availability. Due to the many similarities between pig and human in physiological characteristics, pig can be a good animal model of human diseases with many advantages over the conventional rodent model. The human disease model using genetically modified pigs sees great progress along with the development of embryo manipulation technologies and genetic modification technologies in large mammals. In this paper, the research advances on genetically modified pigs for human disease models in recent years are reviewed.