To investigate the efficiency and the mechanism of the Uygur herb medicine Turkish Gall aqueous(KJA) in treating Ulcerative colitis and Colon cancer, we detect in vitro HT-29 cell apoptotic rate intervened by different concentrations of KJA and in vivo DNCB plus acetic acid induced UC's model rat apoptotic rate, morphological, pathological CMDI grading score changes of colon mucosa after being intervened by KJA. The results were compared between the normal group, the model control group, the mesalazine positive control group, the mesalazine plus KJA group, the KJA gavage group and the KJA enema group in three courses of treatment. It is demonstrated that the KJA would possibly have a therapeutic function in vitro to Colon cancer HT-29 cell by inducing cell apoptosis rate and in vivo to UC in rat by reducing colon mucosa morphological, pathological abnormal damages and inducing the apoptosis rate of colon mucosa damaged cells.