The fracture optimization should be considered in the design for the fracturing constriction before it is put into practice to have more effective fractures. In view of the characteristics of fractured horizontal wells, in this paper, with the concept model of the non-homogeneous media and the low permeability reservoir and with the Eclipse reservoir simulation software, the fracture parameters are optimized, including the fracture azimuth, the fracture position, the fracture number and the non-uniform fracture length. The results show that the production of the horizontal oil increases with the increase of the number, the length and the conductivity of fractures; for different fractural layouts, the fractures are always in the stagger, with the distance among the outer fractures smaller than that among the inner fractures. Because of fracture's mutual interference actions, different fractures are related with different production rates, and the production related with the most inner fractures turns out to be the lowest.