Reviews

Research Progress on Inhibitors of Protein Tyrosine Phosphatase-1B

  • LIU Xia;FENG Changgen
Expand
  • 1. College of Science, China Agricultural University, Beijing 100193, China;2. School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, China

Received date: 2012-02-23

  Revised date: 2012-03-12

  Online published: 2012-04-08

Abstract

Protein-tyrosine phosphatase-1B acts as a negative regulator of the insulin signal transduction, serving as a new therapeutic target in type 2 diabetes and obesity. Inhibitors of PTP-1B may be beneficial in the treatment of type 2 diabetes and obesity. This paper reviews recent progresses of researches on inhibitors of PTP-1B, with PTP-1B inhibitors obtained by chemical synthesis being summarized, including vanadate compounds, phosphate compounds, peptide compounds and others.

Cite this article

LIU Xia;FENG Changgen . Research Progress on Inhibitors of Protein Tyrosine Phosphatase-1B[J]. Science & Technology Review, 2012 , 30(10) : 72 -79 . DOI: 10.3981/j.issn.1000-7857.2012.10.011

Outlines

/