In the mid-west part of China, tight sandstone gas is reserved in a large area. The potential gas and oil source in deep reservoir is tremendous; however as a result of low reservoir porosity and permeability with different manners of migration, both tight gas reservoir with conventional gas-water relation and deep basin gas reservoir with gas-water inversion are developed. It is necessary to discuss the accumulation efficiencies of tight sandstone gas reservoir with the different manners of migration in order to provide valuable references to exploration and practice. For the sake of exploration practice direction of tight sandstone gas reservoir, the methods of theoretic argumentation and physical simulative experiments are used to discuss the accumulation efficiency of tight sandstone gas reservoir which is migrated by faults and by an interface of source rock and tight sandstone, respectively. The results are as follows: Firstly, the accumulation efficiency of migration of an interface of source rock and tight sandstone is better than the efficiency of faults migration and the gas filling volume is higher in a unit time. Secondly, tight sandstone gas reservoir located at the developing belt of fractures needs shorter time to accumulation; however the relation between water and gas is complex in the reservoir. The rationality of the inference is verified by the simulation test. Nevertheless, there are still differences with the temperature and pressure conditions between the laboratory and the actual geological conditions, the results could provide the valuable theory reference for the exploration in the future.