Previous studies suggest that the profiles of over-expressed genes in cervical carcinoma are very different among populations. The aim of this study is to identify the early warning molecular markers specific to Uighur women by screening the cervical lesions for candidate over-expressed genes. 85 cases of fresh cervical tissues were collected from Uighur women with cervical squamous cell carcinoma (CSSC) and chronic cervicitis as well as the normal tissue specimens from the surgical excision of uterus. After preparation of the tissue, the total DNA and RNA, HPV positivity and genotypes were screened by the HPV specific primer PCR, and the transcription level of 7 candidate genes was analyzed by the semi-quantitative RT-PCR. The positive rates of the mRNA expressions of the SPP1, TK1 and ARP2/3 genes are found to be relative low in the chronic cervicitis and the normal periphery of the tumor (25%—28%), and are markedly increased in the CSSC (62%—66%), with a significant difference (P<0.05), but with no significant difference in the expressions of ANX8, HSPAIP, S100-A9 and S100-P genes. In case of the HPV infection, the rates of TK1 and ARP2/3 gene expressions are very low in the HPV negative cases (50.0% and 44.2%), relatively high in the HPV positive cases (82.9% and 74.2%), and with a significant difference (P<0.05). The up regulation of SPP1, TK1 and ARP2/3 gene expressions might serve as an important mark of the cervical cancer progression in Uighur women, and the alteration of TK1 and SPP1 gene expressions may be related with the HPV infection.