Based on the theory of Traditional Uighur Medicine, the metabolites changes in the urine of patients of type two diabetes mellitus with abnormal savda are investigated. 1H Nuclear Magnetic Resonance (NMR) based metabonomic analysis is performed on the urine samples obtained from both abnormal savda patients of type two diabetes mellitus and savda volunteers with normal plasma glucose. The Orthogonal Partial Least-Squares Discriminant Analysis (OPLS-DA) is conducted to distinguish the metabolic phenotypes. The results show that the metabolites in the urine of the patients of type two diabetes mellitus with abnormal savda are significantly changed. The concentrations of glucose, taurine, and betaine are increased (P<0.05); Meanwhile, the concentrations of some amino acids, creatinine, hippurate, citric acid, and dimethylamine are decreased (P<0.05) comparing with savda volunteers with normal plasma glucose. The fact indicates that there are great differences in the urine metabolites between the patients of type two diabetes mellitus with abnormal savda and savda volunteers with normal plasma glucose by using NMR. And it also reveals that endogenous compounds might be the ingredients for the patients of type two diabetes mellitus with abnormal savda.