The expressions of C-erbB-2, MMP-1, MMP-2, MMP-7 and MTA1 in esophageal cancer tissue and normal tissue among the Kazak are studied and the relationship between their expressions and clinical pathological feature is investigated. The expression of C-erbB-2, MMP-1, MMP-2, MMP-7 and MTA1 gene mRNA were detected by using RT-PCR method in 75 esophageal cancer specimens of the Kazak. The results show that the positive rates of C-erbB-2, MMP-1, MMP-2, MMP-7 and MTA1 in cancer tissue are higher than that of normal tissues (P<0.05). While the expression mRNA level of MMP-2, MMP-7 and MTA1 is significantly related to the lymphnode metastasis,And the expression mRNA level of MMP-1, MMP-7 is significantly related to the TNM stages (P<0.05). Kappa analysis indicates that the expressions between C-erbB-2 and MTA1, MMP-2 and MTA1, MMP-7 and MTA1, MMP-7 and MMP-1, MMP-1 and MTA1 in the Kazak's esophageal cancer are positively related (κ=0.624, 0.367, 0.564, 0.275, 0.384, P<0.01) with each other. The conclusion shows that the over expression of C-erbB-2, MMP-1, MMP-2, MMP-7 and MTA1 gene could play the important roles in the carcinogenesis of esophageal cancer in the Kazaks. Their synergistic effect could promote carcinogenesis and development of esophageal cancer. The expressions of MMP-2, MMP-7, and MTA1 might be related to the progression and metastasis of esophageal cancer among the Kazak.