. 2010, 28(24): 82-88.
The effect of abnormal savda on the inducing and developing process of hepatocirrhosis phase in hepatocarcinoma carrying abnormal savda model is studied under the direction of Uighur medicine, establishing the abnormal savda disease rat model serving as a base, using DEN further to establish hepatocarcinoma carrying abnormal savda disease rat model till hepatocirrhosis occurs. The surface of the liver and its pathological and ultrastructural changes in 5th, 7th, 9th, 11th weeks were dynamically observed, respectively. The results show that both in the model control group and the abnormal savda syndrome model group there is the pathological changing process of hepatoxic lesion, hepatic proliferation, hepatocirrhosis, but the pathological changes of the liver surface in the abnormal savda syndrome model group is faster than those in the model control group. At the same time point, the dropsical level of liver cell, typeless hyperplasia, the fake foliole level in liver, the ultrastructural changes of decreasing hepatin and chondriosome in liver cells in abnormal savda syndrome model group exceed those in the model control group. These findings indicate that in the process of establishing abnormal savda disease rat model serving as a base, using DEN further to establish hepatocarcinoma carrying abnormal savda disease rat model, the abnormal savda hilit accelerates the inducing and developing process of hepatocyte to hepatic cellular proliferation andU to hepatocellular carcinoma and this process is similar to the process of human hepatocarcinoma. It is also stable and reliable.
