To study the influence of psychological stress on the tissue structure of the temporomandibular joint, the variation of the tissue structure of the temporomandibular joint was observed under psychological stress in rat. Thirty-six Wister male adult rats were subjected to the following stimulating factors: electroshock, movement constraint, climate change and food tempting, in order to let them under psychological stress (the experimental group). Twelve rats were not subjected to any stimulating actions(the normal control group). Then the rats of the experimental group were executed at three weeks, six weeks and six weeks after ceasing stimulation, each with twelve rats. The control group rats were executed at the same time as the last batch of the experimental group. The change of tissue in temporomandibular joint was observed with microscope. The results show that the collage was exposed and broken in TMJ disc and condyle, especially in rats of the sixth week group. In the recovered group, the condylar cartiage was seen to start to recover. The change of TMJ in each group sees significant difference as a whole, P<0.01. The third week group and the control group, the sixth week group and the control group, the sixth week group and the resumed group were shown to be statistically significantly different, respectively, P<0.05. The others were not statistically significantly different, P>0.05. It is concluded that long time psychological stress can lead to injuries of temporomandibular joint; while these injuries can be recovered by removing the psychological stress.