. 2009, 27(0903): 83-86.
This paper studies the effects on hemodynamics and hemorheology of sand treatments and the free-running of the rabbit experimental knee osteoarthritis. A model of genu OA is established successfully by fixing right hind limbs with gypsum in 20 rabbits. They were divided randomly into free movement group A and free movement added sand treatment group B, and the numerical values of hemodynamics and hemorheology were obtained 20 days after. The results show that: (1) Compare with group A, the blood viscosity of group B in low, middle, high shear rates, the erythrocyte electrophoresis and the volume of packed red blood cells have reduced after intervention (P<0.05); the plasma viscosity, and the shear rate of reduction viscosity in low shear rate have significantly improved after intervention (P<0.01). After the sand treatment, the shear rate of blood viscosity in low, middle, high shear rates, the plasma viscosity, the shear rate of reduction viscosity in low shear rate have significantly improved in group B as compare with before (P<0.01); the shear rate of reduction viscosity in high shear rate and the volume of packed red blood cells have degraded in group B as compare with before (P<0.05). (2) Compare with group A, the numerical values of PS, ED in arteria femoralis of right lower extremity have significantly increased after intervention in group B (P<0.01). After the sand treatment , the numerical values of PS, ED in arteria femoralis of right lower extremity have significantly increased in group B as compare with before (P<0.01), the numerical values of RI have reduced (P<0.05). The conclusion is that the sand treatment in Uyghur medicine could improve blood viscosity, reduce Peripheral Vascular Resistance (PVR) of the rabbit experimental knee osteoarthritis, meanwhile it could accelerate blood flow rate and lessen vascular resistance in arteria cruralis of the lower limbs in rabbit. This is one of the causes which sand treatment plays a role in anti-inflammatory action.