. 2006, 24(0604): 44-48.
Objective: Taking primary osteoporosis as example, this study was designed to evaluate three therapeusis by multidimensional, especially biology, social psychology and health economics indexes and to provide new pathway and methods for the elder's diseases and the other chronic disease comprehensive evaluation. Methods: The three therapeusis are Vit D+ Ca, estrogen and diphosphonates. The biology indexes are bone mineral density of lumbar (L1-4), total lumbar, thighbone neck and Ward's triangle area. The social psychology indexes are quality of life SF-36 eight dimensionalities and sum total. The health economics indexes are drug cost, examine cost and total cost. Results: ① According to the bone mineral density, the estrogen treatment's effect was significantly worse than before at L-1, ;L-2 and L-Total,VitD+ Ca treatment was significantly worse than before at L-2 and the others were not significant. ② According to the quality of life , the Estrogen treatment effect was significantly better than before at RP and RE, diphosphonates treatment had significant difference at SF and GH,three therapeusis were significantly better than before at SF-36 Total. ③ According to the medical cost, by the end of the first follow-up, there were no significant statistical difference among the three therapeusis and by the end of the second followed-up, the drug cost was significant statistical different and the Vit D+ Ca was cheaper than the others. ④ According to the Data Envelopment Analysis, the data of first follow-up show that DEA of both diphosphonates treatment and estrogen treatment were useful (θ=1), and DEA of Vit D + Ca treatment was not useful (θ<1 ). The bone mineral density of Vit D + Ca treatment could be improved further according to the relaxation variable. The second follow-up showed that DEA of all the three treatments were useful, and all the relaxation variables were zero. Conclusion: ① According to the bone mineral density, the diphosphonates is the best; According to the quality of life, estrogen is the best and according to the cost, the Vit D + Ca is the best. According to the three aspects, in short-term effect,the effect of estrogen and diphosphonates are equivalent, and VitD+ Ca is relative worst; but in long-term effect,the three treatment are equivalent. ② Evaluation of therapeusis may take the different conclusions if clinical practices consider only one aspect. The A index implicates the different result from the B index as well as th
