. 2005, 23(0507): 9-16.
Human Immunodeficiency Virus (HIV) is the pathogen of AIDS. Research on HIV etiology is the basis of understanding HIV pathogenesis, searching for the targets of antiretroviral therapy, designing of effective HIV vaccine and diagnostic methods. Since HIV was isolated in 1983, the biology study has made great progress. The shape, structure and function of each ingredient of the viral particle have been clarified. The replication and life cycle of the virus have been understood, the control and regulation of virus replication have been revealed. The dynamic and variation of the virus have been comprehended. On the basis of the these knowledge, the pathogenesis of HIV and the interaction between HIV and host cell have been bright to light. However, HIV antiretroviral therapy and specific immune prevention are still great problems, the advanced research on HIV biology and pathogenesis is urgently needed for revealing molecular mechanism of HIV replication, regulation and pathogenesis, clar ifying the interaction between HIV and host cell and development of new antiretroviral agents and vaccine.
