LI Yu, REN Xiang, LIU Di, CHENG Ying, GAO George Fu, YU Hongjie
Ebolavirus is the causative agent of Ebola Virus Disease (EVD) and was first found in 1976 in Africa. The genus of Ebolavirus includes 5 species, of which the 4 species, i.e., Sudan ebolavirus, Zaire ebolavirus, Taï Forest ebolavirus and Bundibugyo ebolavirus caused human cases of EVD in the history. The additional species, Reston ebolavirus, was associated with several outbreaks among monkeys and was once isolated from domestic pigs of Philippines. EVD has a fatality rate between 25% and 90%, with its outbreaks in humans limited to Africa and mainly happened in central Africa between 10°N and 10°S so far. The ongoing outbreak in West Africa has been the biggest one, with 2615 cases reported as of August 20, 2014. EVD is widely considered to be a zoonosis and its most likely natural reservoirs are fruit bats based on the current evidence. Ebolavirus can spread within human, mainly through contact of blood and secretions of patients presenting symptoms and the contaminated objects as well. So the health care staff, home care person and individuals with contact of corpse of EVD cases are the high risk population for infection. EVD has an abrupt onset of early symptoms such as fever, anorexia and weakness, which are nonspecific. But the disease can be diagnosed through testing RNA, antigen, or antibody. There have been no licensed drugs or vaccine in the market, while the treatment is still limited to treating the symptoms as they appear and supportive care. The current strategy for prevention and control includes early detection of cases, rapid investigation and response, tracing and close observation of high risk contact, and effective infection control in the health care facilities and the community.