. 2010, 28(15): 79-82.
To develop the optimal alcohol extraction technology of Gancao, Dijincao, Tiexianjue in the Abnormal Savda Munziq Granula, with the content and the amount of alcohol extractive of glycyrrhizin as index, single factor experiments were carried out. The four factors that influence the extraction result, the quantity and the concentration of alcohol, the extracting time and the frequency, were optimized. The extracting process is as follows: to extract twice with 55%, 65%, 75% alcohol, of amount of 10, 12, 14 times, 1.0, 1.5 and 2.0 hours each time. Then the L9(34) orthogonal design is used to find the best alcohol extraction technology of Gancao, Dijincao, Tiexianjue,
Xiangqinglan. A balanced sampling is adopted in the range of each key factor to make each experiment highly representative. With the well-distributed nature of these factors, the orthogonal layout can ensure all experiments serve their purpose. The results show that the extracting time and amount do not have marked influence but the concentration of alcohol does. Due to the insignificant influence of the amount of alcohol and the extracting time, the optimum extraction technology A2B2C3 may be replaced by A2B1C1, that is, to extract twice with 65% alcohol, of amount of 10 times, 1 hour each time. The extraction method is reasonable, feasible and convenient to be applied to production. The preparation technology for Abnormal Savda Munziq Granular can be similarly obtained.